Influence of Chemotherapeutic Drugs and Estrogen on LDH, C.K. Levels, and Chromosomal Aberrations in Mice

Background: Chemotherapy drugs like vincristine (VCR) and doxorubicin (Doxo) are widely used to treat cancer but can also harm healthy cells. Estrogen, a hormone involved in many bodily functions, might help reduce some of these side effects. This study explores how estrogen affects the biological and genetic responses to VCR and Doxo in female mice. Methods: Female mice were divided into groups and given either estrogen, VCR, or Doxo, alone or in combination. Blood tests were done to measure levels of lactate dehydrogenase (LDH) and creatine kinase (C.K.), two enzymes that reflect tissue health. Chromosomal changes in bone marrow cells were also examined under a microscope. Results: Mice treated with VCR and Doxo showed more chromosomal damage and changes in enzyme levels. Estrogen on its own raised enzyme levels but didn?t cause genetic damage. When given with chemotherapy, estrogen reduced both enzyme fluctuations and chromosomal issues, especially with VCR. Conclusion: Estrogen appears to lessen the harmful effects of certain chemotherapy drugs. These findings suggest that it may be helpful in reducing side effects in cancer treatments.